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Diabetes and Other Endocrine Diseases Research

We conduct research on treatment patterns, clinical outcomes, costs and utilization in diabetes and other endocrine diseases.

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Proven research expertise

Researchers on the Optum® HEOR Endocrine-Metabolic team have expertise in epidemiology, biostatistics, health services research, pharmacology and basic science.

Our team applies their expertise to design, execute, and interpret findings from health economics and outcomes studies of endocrine diseases and disorders of metabolism, such as diabetes.

Optum HEOR has published over 100 peer-reviewed manuscripts in the diabetes research domain alone. In addition to diabetes, their work has spanned the spectrum of chronic disease including cardiovascular, renal, liver, respiratory diseases and osteoporosis.

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Providing insight into chronic conditions


  • Adherence to new therapies such as SLGT-2 inhibitors and DPP-4 inhibitors
  • Early versus late treatment intensification
  • Loose pill versus fixed dose combination therapies
  • Real world assessment of HbA1c outcomes with injectable therapy
  • Burden of hypoglycemia


  • Patient characteristics associated with frequent flares
  • Economic implications of frequent flares
  • Real-world assessment of costs and utilization in patients initiating gout treatment

Other endocrine conditions and disorders of metabolism

  • Cystic fibrosis
  • Pancreatic enzyme insufficiency
  • Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH)
  • Central precocious puberty
  • Hyper- and hypothyroidism
  • Obesity

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