Determining lines of therapy (LOT) regimens

Identifying a LOT impacts clinical and economic outcomes. 


Establishing rules and guidelines to determine lines of therapy (LOT) in claims-based retrospective studies in oncology is beneficial. Having LOT in place helps determine the clinical benefit and the economic impact of specific treatment regimens.

LOT are not explicitly available in claims data, so implementing algorithms with rules for initiation, discontinuation, restarting and switching of therapies is important. Optum® offers guidance on setting guidelines for determining LOT regimens and durations.

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